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@@ -557,8 +557,9 @@ How much mechanistic detail is needed here? My work doesn't really go into
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\begin_layout Standard
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\begin_layout Standard
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Because an allograft comes from a different person, it is genetically distinct
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Because an allograft comes from a different person, it is genetically distinct
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from the rest of the recipient's body.
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from the rest of the recipient's body.
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- Some genetic variants occur in protein coding regions, resulting in protein
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- products that differ from the equivalent proteins in the graft recipient's
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+ Some genetic variants occur in protein coding regions and affect the polypeptid
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+e sequences encoded by the affected genes, resulting in protein products
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+ that differ from the equivalent proteins produced by the graft recipient's
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own tissue.
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own tissue.
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As a result, without intervention, the recipient's immune system will eventuall
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As a result, without intervention, the recipient's immune system will eventuall
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y identify the graft as foreign tissue and begin attacking it, eventually
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y identify the graft as foreign tissue and begin attacking it, eventually
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