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@@ -1282,7 +1282,18 @@ In addition to other considerations, if called peaks are to be used as regions
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to call peaks in a way that is blind to differential abundance between
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experimental conditions, or else the statistical significance calculations
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for differential abundance will overstate their confidence in the results.
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- The csaw package provides guidelines for calling peaks in this way: peaks
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+ The
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+
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+\begin_inset Flex Code
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+status open
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+
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+\begin_layout Plain Layout
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+csaw
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+\end_layout
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+
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+\end_inset
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+
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+ package provides guidelines for calling peaks in this way: peaks
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are called based on a combination of all ChIP-seq reads from all experimental
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conditions, so that the identified peaks are based on the average abundance
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across all conditions, which is independent of any differential abundance
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@@ -1369,7 +1380,18 @@ literal "false"
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\begin_layout Standard
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In ChIP-seq data, normalization is not as straightforward.
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- The csaw package implements several different normalization strategies
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+ The
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+
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+\begin_inset Flex Code
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+status open
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+
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+\begin_layout Plain Layout
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+csaw
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+\end_layout
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+
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+\end_inset
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+
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+ package implements several different normalization strategies
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and provides guidance on when to use each one
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\begin_inset CommandInset citation
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LatexCommand cite
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@@ -3054,7 +3076,18 @@ PCoA plots of ChIP-seq sliding window data, before and after subtracting
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\begin_layout Standard
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Reads in promoters, peaks, and sliding windows across the genome were counted
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- and normalized using csaw and analyzed for differential modification using
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+ and normalized using
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+
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+\begin_inset Flex Code
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+status open
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+
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+\begin_layout Plain Layout
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+csaw
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+\end_layout
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+
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+\end_inset
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+
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+ and analyzed for differential modification using
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\begin_inset Flex Code
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status open
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