Thesis/presentation.mkdn

% Title: naïve and memory CD4 T-cell activation
% Ryan C. Thompson \
  Su Lab \
  The Scripps Research Institute
% October 24, 2019

# Intro

# Biological motivation: Transplant rejection

## Organ transplants are a life-saving treatment for many

\Large

* 36,528 transplants performed in the USA in 2018[^1]

. . .

* 100 transplants every day!

. . .

* Over 113,000 people on the national transplant waiting list as of
  July 2019

[^1]: Source: https://www.organdonor.gov/statistics-stories/statistics.html

## Organ transplants are a life-saving treatment for many

![Organ donation statistics for the USA in 2018[^2]](graphics/presentation/transplants-organ-CROP.pdf){ height=70% }

[^2]: Source: https://www.organdonor.gov/statistics-stories/statistics.html

## Rejection is an adaptive immune response against a graft

* The host's adaptive immune system identifies and attacks cells
  bearing non-self antigens

. . .

* An allograft contains differnet genetic variants from the host,
  resulting in protein-coding differences

. . .

* Left unchecked, the host immune system eventually notices these
  alloantigens and begins attacking (rejecting) the graft

. . .

\Large

* Rejection is the major long-term threat to organ allografts

## Allograft rejection remains a major long-term problem

![Kidney allograft survival rates in children by transplant year[^3]](graphics/presentation/kidney-graft-survival.png){ height=65% }

[^3]: Kim & Marks. "Long-term outcomes of children after solid organ transplantation". In: Clinics (2014)

## Immune memory is a significant contributor to rejection

![Memory T-cells proliferate and respond more quickly](graphics/presentation/T-cells-SVG.pdf)

# Figure Storage

## Slides
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<!-- ![Figure](graphics/CD4-csaw/Promoter-Peak-Distance-Profile-PAGE1-CROP.pdf) -->

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