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@@ -149,16 +149,10 @@ and memory $\mathsf{CD4}^{+}$ T-cell activation
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-## Memory cells are a problem for immune suppression
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-
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-<!-- Need graphics? Or maybe just mark this slide as speaker notes for the previous one -->
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-
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-\large
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+::: notes
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Compared to naïve cells, memory cells:
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-\normalsize
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-
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* respond to a lower antigen concentration
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* respond more strongly at any given antigen concentration
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* require less co-stimulation
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@@ -166,6 +160,8 @@ Compared to naïve cells, memory cells:
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naïve cells
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* evolve over time to respond even more strongly to their antigen
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+:::
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+
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## Memory cells are a problem for immune suppression
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\large
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@@ -209,6 +205,18 @@ Result:
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Data generated by Sarah Lamere, published in GEO as
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[GSE73214](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE73214)
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+## ChIP-seq sequences DNA bound to marked histones[^chipseq]
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+
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+\centering
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+
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+{ height=70% }
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+
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+[^chipseq]: [Furey. "ChIP-seq and beyond: New and improved methodologies to detect and characterize protein-DNA interactions". In: Nature Reviews Genetics (2012)](http://www.nature.com/articles/nrg3306)
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+
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+## H3K4me2, H3K4me3, H3K27me3
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+
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+Why? <!-- TODO -->
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+
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## A few intermediate analysis steps are required
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