|
@@ -1013,34 +1013,6 @@ name "sec:Biological-motivation"
|
|
Biological motivation
|
|
Biological motivation
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Find some figures to include even if permission is not obtained.
|
|
|
|
- Try to obtain permission, and if it cannot be obtained, remove/replace
|
|
|
|
- them later.
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Rethink the subsection organization after the intro is written.
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Subsection
|
|
\begin_layout Subsection
|
|
Rejection is the major long-term threat to organ and tissue allografts
|
|
Rejection is the major long-term threat to organ and tissue allografts
|
|
\end_layout
|
|
\end_layout
|
|
@@ -6479,23 +6451,6 @@ Result of RNA-seq batch-correction using MOFA latent factors
|
|
Results
|
|
Results
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Focus on what hypotheses were tested, then select figures that show how
|
|
|
|
- those hypotheses were tested, even if the result is a negative.
|
|
|
|
- Not every interesting result needs to be in here.
|
|
|
|
- Chapter should tell a story.
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Subsection
|
|
\begin_layout Subsection
|
|
Interpretation of RNA-seq analysis is limited by a major confounding factor
|
|
Interpretation of RNA-seq analysis is limited by a major confounding factor
|
|
\end_layout
|
|
\end_layout
|
|
@@ -7471,19 +7426,6 @@ noprefix "false"
|
|
histones.
|
|
histones.
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Standard
|
|
\begin_layout Standard
|
|
All 3 histone marks tend to occur more often near promoter regions, as shown
|
|
All 3 histone marks tend to occur more often near promoter regions, as shown
|
|
in Figure
|
|
in Figure
|
|
@@ -10164,20 +10106,6 @@ Gene expression grouped by promoter coverage clusters.
|
|
\end_inset
|
|
\end_inset
|
|
|
|
|
|
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Repeated figure legends are kind of an issue here.
|
|
|
|
- What to do?
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
\begin_layout Plain Layout
|
|
\begin_layout Plain Layout
|
|
@@ -10400,19 +10328,6 @@ I forgot until recently about the work I did on this.
|
|
Discussion
|
|
Discussion
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Write better section headers
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Subsection
|
|
\begin_layout Subsection
|
|
Each histone mark's
|
|
Each histone mark's
|
|
\begin_inset Quotes eld
|
|
\begin_inset Quotes eld
|
|
@@ -11412,32 +11327,6 @@ MACS
|
|
y.
|
|
y.
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Note Note
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Subsection
|
|
|
|
-Data quality issues limit conclusions
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Is this needed?
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Section
|
|
\begin_layout Section
|
|
Future Directions
|
|
Future Directions
|
|
\end_layout
|
|
\end_layout
|
|
@@ -12243,10 +12132,15 @@ Fill this out
|
|
Arrays for diagnostics
|
|
Arrays for diagnostics
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
|
|
+\begin_layout Plain Layout
|
|
Arrays are an attractive platform for diagnostics
|
|
Arrays are an attractive platform for diagnostics
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
|
|
+\end_inset
|
|
|
|
+
|
|
|
|
+
|
|
|
|
+\end_layout
|
|
|
|
+
|
|
\begin_layout Subsection
|
|
\begin_layout Subsection
|
|
Proper pre-processing is essential for array data
|
|
Proper pre-processing is essential for array data
|
|
\end_layout
|
|
\end_layout
|
|
@@ -14022,32 +13916,6 @@ literal "false"
|
|
Results
|
|
Results
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Improve subsection titles in this section.
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Reconsider subsection organization?
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Subsection
|
|
\begin_layout Subsection
|
|
Separate normalization with RMA introduces unwanted biases in classification
|
|
Separate normalization with RMA introduces unwanted biases in classification
|
|
\end_layout
|
|
\end_layout
|
|
@@ -17037,20 +16905,6 @@ wide false
|
|
sideways false
|
|
sideways false
|
|
status collapsed
|
|
status collapsed
|
|
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-\align center
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Consider transposing these tables
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Plain Layout
|
|
\begin_layout Plain Layout
|
|
\begin_inset Float table
|
|
\begin_inset Float table
|
|
wide false
|
|
wide false
|
|
@@ -18624,20 +18478,6 @@ SVA
|
|
Future Directions
|
|
Future Directions
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Some work was already being done with the existing fRMA vectors.
|
|
|
|
- Do I mention that here?
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Subsection
|
|
\begin_layout Subsection
|
|
Improving fRMA to allow training from batches of unequal size
|
|
Improving fRMA to allow training from batches of unequal size
|
|
\end_layout
|
|
\end_layout
|
|
@@ -21662,27 +21502,6 @@ GB
|
|
expression.
|
|
expression.
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Standardize on
|
|
|
|
-\begin_inset Quotes eld
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-log2
|
|
|
|
-\begin_inset Quotes erd
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
- notation
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
\begin_layout Standard
|
|
\begin_layout Standard
|
|
The data do indeed show small systematic perturbations in gene levels (Figure
|
|
The data do indeed show small systematic perturbations in gene levels (Figure
|
|
|
|
|
|
@@ -21889,19 +21708,6 @@ edgeR
|
|
\end_inset
|
|
\end_inset
|
|
|
|
|
|
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\begin_layout Standard
|
|
|
|
-\begin_inset Flex TODO Note (inline)
|
|
|
|
-status open
|
|
|
|
-
|
|
|
|
-\begin_layout Plain Layout
|
|
|
|
-Give these numbers the LaTeX math treatment
|
|
|
|
-\end_layout
|
|
|
|
-
|
|
|
|
-\end_inset
|
|
|
|
-
|
|
|
|
-
|
|
|
|
\end_layout
|
|
\end_layout
|
|
|
|
|
|
\begin_layout Standard
|
|
\begin_layout Standard
|