resume/ryan_thompson_resume.lyx

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\fancyfoot[R]{\footnotesize{Online version (with links): \href{https://darwinawardwinner.github.io/resume/ryan_thompson_resume.pdf}{https://darwinawardwinner.github.io/resume/ryan\_{}thompson\_{}resume.pdf}}}
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\begin_body

\begin_layout Standard
\begin_inset Flex CV Image
status open

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headshot-crop.png
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\begin_layout CV Name
Ryan C.
 Thompson
\end_layout

\begin_layout Contact Address
8656 Via Mallorca
\begin_inset Newline newline
\end_inset

Unit G
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\end_inset

La Jolla, CA 92037
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\begin_layout Phone Number
(908)
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\end_inset

922-7470
\end_layout

\begin_layout Email
rct@thompsonclan.org
\end_layout

\begin_layout Website
https://github.com/DarwinAwardWinner
\end_layout

\begin_layout Section
Summary
\end_layout

\begin_layout Itemize
Accomplished, experienced computational biologist with deep knowledge of
 biology, mathematics, statistics, and programming
\begin_inset Note Note
status open

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Underplays math/stats knowledge?
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\begin_layout Itemize
11 years of bioinformatics experience answering a wide range of complex
 biological questions through analysis of large NGS- and microarray-based
 whole transcriptome and epigenetic data sets
\end_layout

\begin_layout Itemize
Strong focus on sound statistical analysis, effective data visualization
 and communication, and making expert knowledge and successful analysis
 methods available as re-usable software tools
\begin_inset Note Note
status open

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Work in machine learning?
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\begin_layout Itemize
Supportive team member with a strong ability to foster cross-disciplinary
 literacy by explaining concepts at the right level of abstraction
\end_layout

\begin_layout Section
Education
\end_layout

\begin_layout Description
The
\begin_inset space \space{}
\end_inset

Scripps
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Research
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Institute 
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Ph.
 D.
 in Bioinformatics, 2019
\end_layout

\begin_layout Description
University
\begin_inset space \space{}
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of
\begin_inset space \space{}
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Virginia 
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B.S.
 in Biology, B.A.
 in Mathematics, 2009 
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Mention high distinction
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Echols Scholar
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Research Experience
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\begin_layout Subsection
Salomon Lab, The Scripps Research Institute 
\begin_inset space \hfill{}
\end_inset

 La Jolla, CA
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 2012 - 2019
\end_layout

\begin_layout Description
Contact: Dr.
 Andrew Su, 
\begin_inset CommandInset href
LatexCommand href
name "asu@scripps.edu"
target "asu@scripps.edu"
type "mailto:"
literal "false"

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Double-check all contact emails
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\begin_layout Standard
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Lacking impact statement.
 Say what I did and what the impact was.
 Also say methodology applied.
 First sentence: problem statement.
 2nd sentence: methodology applied.
 3rd sentence: impact/result/take-home
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\begin_layout Itemize
Created an open source, reproducible workflow to analyze a large multi-omics
 next-gen sequencing dataset of 220 RNA-seq and ChIP-seq samples to reveal
 interactions between differential histone methylation and differential
 gene expression during T-cell activation, as well as key differences in
 activation between naïve and memory cells 
\begin_inset CommandInset citation
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key "lamere2016,lamere2017-JMJD3"
literal "true"

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.
 
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Add any new publications
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Links: 
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LatexCommand href
name "Reproducible workflow"
target "https://github.com/DarwinAwardWinner/CD4-csaw#re-analysis-of-a-combined-chip-seq--rna-seq-data-set"
literal "false"

\end_inset

, 
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LatexCommand href
name "Slides"
target "https://darwinawardwinner.github.io/resume/examples/Salomon/CD4/ChIP-Seq%20presentation.pdf"
literal "false"

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, 
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LatexCommand href
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\begin_layout Itemize
Significantly improved performance of machine learning classifier for identifyin
g transplant rejection by developing appropriate single-sample microarray
 normalization procedures
\begin_inset CommandInset citation
LatexCommand cite
key "kurian2014molecular"
literal "true"

\end_inset

, including training a custom set of frozen RMA normalization vectors.
 Classifier is currently being developed into a clinical test for transplant
 dysfunction.
 
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status open

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Work in the word biomarker, cross validation
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Links: 
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LatexCommand href
name "fRMA example code & plots"
target "https://darwinawardwinner.github.io/resume/examples/Salomon/fRMA/"
literal "false"

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, 
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LatexCommand href
name "Classifier Method Write-up"
target "https://darwinawardwinner.github.io/resume/examples/Salomon/Classifier%20Math%20Write-up.pdf"
literal "false"

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\begin_layout Itemize
Performed a comprehensive comparative evaluation of over 20 subtly different
 statistical models for differential methylation in Illumina 450k arrays,
 selecting a model that best explained the observed sources and trends of
 variation in the data, including cross-domain application of a method originall
y designed for RNA-seq data.
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Link: 
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\begin_layout Itemize
Evaluated and optimized cost and performance of custom protocol for RNA-seq
 of human and primate blood samples while minimizing nuisance globin reads.
 Increased yield of useful reads nearly 2-fold.
 
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key "globin-reduction"
literal "true"

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Link: 
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LatexCommand href
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Investigated effects of life-span-extending drug on worm gene expression
 over time revealing that the drug retards age-related 
\begin_inset Quotes eld
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transcriptional drift
\begin_inset Quotes erd
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, preserving a youthful phenotype at the molecular level.
 
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key "Rangarajue08833"
literal "true"

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Link: 
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LatexCommand href
name "PCoA Plot"
target "https://darwinawardwinner.github.io/resume/examples/Salomon/mdsplots-multidim.pdf"
literal "false"

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\begin_layout Itemize
Implemented a systems biology tool to analyze and efficiently present and
 summarize differential expression for multiple gene set & pathway methods
 run on multiple pathway databases, as well as differential expression of
 individual genes within each pathway.
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\end_inset

Links: 
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LatexCommand href
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target "https://darwinawardwinner.github.io/resume/examples/Salomon/Pathways/Pathway%20Presentation.pdf"
literal "false"

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, 
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, 
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literal "false"

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\begin_layout Itemize
Performed comparative analysis of multiple differential expression statistical
 models to define best practice for optimal sensitivity while maintaining
 false positive control.
 Presented on theoretical and practical similarities and differences between
 methods.
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Links: 
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target "https://darwinawardwinner.github.io/resume/examples/Salomon/DGE%20Presentation.pdf"
literal "false"

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, 
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, 
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literal "false"

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\begin_layout Itemize
Taught basic RNA-seq theory and practical analysis for the graduate-level
 introductory bioinformatics course.
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Links: 
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name "Lecture Slides"
target "https://darwinawardwinner.github.io/resume/examples/Salomon/Teaching/RNA-Seq Lecture.pdf"
literal "false"

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, 
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literal "false"

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\begin_layout Itemize
Adapted common normalization methods from RNA-seq to improve performance
 in analysis of RASL-seq experiments.
 
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key "Scott036061"
literal "true"

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\begin_layout Itemize
Active member of the Bioconductor community and contributing developer for
 several Bioconductor packages.
 
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Links: 
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, 
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Check bioc package links, add any additional ones?
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\begin_layout Itemize
Mentored 2 coworkers in learning bioinformatics, one from a programming
 background and the other from a biology background.
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Mentored how many?
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\begin_layout Subsection
Summer Internship, Informatics IT, Merck & Co.
 
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 Boston, MA
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 2011
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\begin_layout Description
Contact: Adnan Derti, 
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Notify Adnan
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\begin_layout Itemize
Built a transcriptome assembly and quantification pipeline using Cufflinks,
 including fully-automated cluster job control for high-throughput reproducible
 analysis, and presented a conceptual overview of Cufflinks' assembly and
 quantification algorithms to help the team understand Cufflinks.
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Link: 
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LatexCommand href
name "Presentation Slides"
target "https://darwinawardwinner.github.io/resume/examples/cufflinks-presentation.pdf"
literal "false"

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\end_layout

\begin_layout Itemize
Assisted in a molecular genetics study to evaluate peformance of two variant
 calling algorithms in detection of causal mutations in antibiotic-resistant
 bacterial genomes.
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\begin_layout Subsection
Gaasterland Lab, UCSD Bioinformatcs 
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 La Jolla, CA
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 2010 - 2012
\end_layout

\begin_layout Description
Contact: Terry Gaasterland, 
\begin_inset CommandInset href
LatexCommand href
name "gaasterland@ucsd.edu"
target "gaasterland@ucsd.edu"
type "mailto:"
literal "false"

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\begin_layout Itemize
Designed and implemented Deloxer, a critical software step in a new Illumina
 mate-pair sequencing protocol using Cre recombination.
 Deloxer is published
\begin_inset CommandInset citation
LatexCommand cite
key "van2011illumina"
literal "true"

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 and now in use in several labs around the world.
 
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Links: 
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LatexCommand href
name "Documentation"
target "http://genomes.sdsc.edu/downloads/deloxer/index.html"
literal "false"

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; 
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name "Code"
target "https://darwinawardwinner.github.io/resume/examples/Gaasterland/delox.R.html"
literal "false"

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\begin_layout Itemize
Performed a molecular genetics study to find potential causal mutations
 for 
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LatexCommand href
name "fatal iron overload disease"
target "https://en.wikipedia.org/wiki/Black_rhinoceros#Threats"
literal "false"

\end_inset

 in critically endangered black rhinoceros by 
\emph on
de novo
\emph default
 assembly of transcriptomes for black rhino and closely-related white rhino.
 Developed a custom pipeline to match up ortholog gene pairs, discover single-nu
cleotide differences between them, and functionally annotate these differences,
 and delivered a list of potential causal variants to collaborators for
 follow-up.
 
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Link: 
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LatexCommand href
name "Example results"
target "https://darwinawardwinner.github.io/resume/examples/Gaasterland/ipi-results-small.txt"
literal "false"

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\begin_layout Itemize
Helped design & implement a large-scale high-throughput exome sequencing
 pipeline for SNP discovery and functional annotation, including QC and
 validation of on-target coverage depth and reproducibility of coverage.
 
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Links: 
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LatexCommand href
name "Example 1"
target "https://darwinawardwinner.github.io/resume/examples/Gaasterland/neartarget.pdf"
literal "false"

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; 
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LatexCommand href
name "Example 2"
target "https://darwinawardwinner.github.io/resume/examples/Gaasterland/on-off-coverage.pdf"
literal "false"

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; 
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LatexCommand href
name "Example 3"
target "https://darwinawardwinner.github.io/resume/examples/Gaasterland/depth-consistency.pdf"
literal "false"

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\begin_layout Itemize
Created a fully-automated pipeline to produce quality-control metrics and
 plots for Illumina high-throughput sequencing data for early identification
 of failed runs or samples.
 
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Link: 
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LatexCommand href
name "Example results"
target "https://darwinawardwinner.github.io/resume/examples/Gaasterland/illumina-qc.png"
literal "false"

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\begin_layout Itemize
Investigated the binding motif specificity of ZASC1 transcription factor
 in mouse T-cells using Affymetrix expression microarrays in ZASC1 siRNA
 knockdown experiment.
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Analyzed miRNA target predictions using GO & KEGG grouping to identify target
 pathways of autophagy-related miRNAs for biological validation.
 
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Link: 
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LatexCommand href
name "Example results"
target "https://darwinawardwinner.github.io/resume/examples/Gaasterland/mirna-results.html"
literal "false"

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\begin_layout Subsection
Timko Lab, U.
 of Virginia Biology 
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\end_inset

 Charlottesville, VA
\begin_inset space \qquad{}
\end_inset

 2007 - 2009
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\begin_layout Description
Contact: Paul J.
 Rushton, 
\begin_inset CommandInset href
LatexCommand href
name "Paul.Rushton@sdstate.edu"
target "Paul.Rushton@sdstate.edu"
type "mailto:"
literal "false"

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\end_layout

\begin_layout Itemize
Undergraduate thesis: Designed and implemented Contig Farmer, an algorithm
 for efficient selective contig assembly starting from “seed” sequences
 of interest, and used Contig Farmer to accelerate transcription factor
 gene discovery in cowpea and tobacco shotgun genomic sequence data
\begin_inset CommandInset citation
LatexCommand cite
key "cfarmer"
literal "true"

\end_inset

.
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\begin_layout Itemize
Investigated transcription factors mediating plant stress response using
 expression microarray time-course, and refined the custom microarray design
 using data from previous runs to identify and eliminate uninformative probes,
 yielding an improved design for future studies.
 
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\end_inset

Link: 
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LatexCommand href
name "Code"
target "https://darwinawardwinner.github.io/resume/examples/UVa/probe-selection.R.html"
literal "false"

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\begin_layout Itemize
Acted as interpreter to explain complex biological concepts to programmers
 and explain complex computational problems to biologists.
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Link: 
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LatexCommand href
name "Presentation Slides"
target "https://darwinawardwinner.github.io/resume/examples/UVa/blast-slides.pdf"
literal "false"

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\begin_layout Section
Skills
\end_layout

\begin_layout Description
Computing
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\end_inset

Skills R/BioConductor, Python, Perl, Lisp, Java, C#, C++; Git version control;
 Remote UNIX system administration & software compilation, computing cluster
 job management & parallel computation
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\end_inset

Public code: 
\begin_inset CommandInset href
LatexCommand href
target "https://github.com/DarwinAwardWinner"
literal "false"

\end_inset

 
\begin_inset Newline newline
\end_inset

StackOverflow Profile: 
\begin_inset CommandInset href
LatexCommand href
target "http://stackoverflow.com/users/125921"
literal "false"

\end_inset

 
\end_layout

\begin_layout Description
Statistics,
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\end_inset

Machine
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\end_inset

Learning,
\begin_inset space ~
\end_inset

&
\begin_inset space ~
\end_inset

Data
\begin_inset space ~
\end_inset

Analysis Multi-omics NGS & microarray analysis, multi-factor linear and
 generalized linear regression, experimental design and parametrization,
 empirical Bayesian methods, predictive modeling of clinical outcomes, machine
 learning classifier training & validation, survival analysis, data visualizatio
n & presentation, reproducible research practices
\end_layout

\begin_layout Description
Wet
\begin_inset space ~
\end_inset

Lab: PCR, molecular cloning, recombinant protein purification, epitope mapping,
 site-directed mutagenesis, 2D gels, real-time PCR, and associated data
 analysis 
\end_layout

\begin_layout Description
Languages: English: native speaker; German: written and spoken
\end_layout

\begin_layout Section
Other Work Experience
\end_layout

\begin_layout Subsection
Computing Advisor & Help Desk, U.
\begin_inset space \thinspace{}
\end_inset

Va.
 IT Dept.
 
\begin_inset space \hfill{}
\end_inset

 Charlottesville, VA 
\begin_inset space \qquad{}
\end_inset

 2005 - 2007 
\end_layout

\begin_layout Itemize
Provided support via phone and on-site for students, faculty, and staff
 having problems with computers, phone system, network access, malware,
 hardware setup, and university web services
\end_layout

\begin_layout Itemize
Tasks included support for university-provided software, virus removal,
 iPod recovery, printer setup and repair, diagnosis of hardware malfunctions,
 and data recovery from failing hard disks
\end_layout

\begin_layout Subsection
Summer Sailing Instructor, Raritan Yacht Club 
\begin_inset space \hfill{}
\end_inset

 Perth Amboy, NJ 
\begin_inset space \qquad{}
\end_inset

 2006 - 2009 
\end_layout

\begin_layout Itemize
Instructed children ages 8-18 in sailing skills, safety, seamanship, knots,
 rigging & de-rigging boats, navigation, and racing strategy and technique,
 with an emphasis on building character and self-reliance
\end_layout

\begin_layout Itemize
Ensured safety of students and staff by maintaining boats and equipment
 in good repair, by being vigilant to traffic and hazards on a busy waterway,
 and by communicating and coordinating efficiently with other staff
\end_layout

\begin_layout Itemize
Helped organize, run, and referee several regattas per season for students
 from RYC and neighboring yacht clubs
\end_layout

\begin_layout Standard
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status open

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The following command changes the title of the bibliography and also un-does
 the indentation of it
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\backslash
renewcommand{
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\backslash
hspace{-116pt}Writings and Publications}
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status open

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Update references.
 Change RASL-seq from 
\begin_inset Quotes eld
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in review
\begin_inset Quotes erd
\end_inset

 to just link to the preprint
\end_layout

\end_inset


\end_layout

\begin_layout Standard
\begin_inset CommandInset bibtex
LatexCommand bibtex
btprint "btPrintAll"
bibfiles "citations"
options "plainyr-rev"

\end_inset


\end_layout

\begin_layout Standard
\begin_inset Note Note
status open

\begin_layout Plain Layout
Add section on talks
\end_layout

\end_inset


\end_layout

\end_body
\end_document