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%% This BibTeX bibliography file was created using BibDesk.
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%% http://bibdesk.sourceforge.net/
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-%% Created for Ryan C. Thompson at 2017-01-26 14:00:34 -0800
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+%% Created for Ryan C. Thompson at 2017-03-31 14:12:45 -0700
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%% Saved with string encoding Unicode (UTF-8)
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@@ -23,8 +23,8 @@
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Abstract = {The changes to the epigenetic landscape in response to antigen during CD4 T cell activation have not been well characterized. While CD4 T cell subsets have been mapped globally for numerous epigenetic marks, little has been done to study their dynamics early after activation. We have studied changes to promoter H3K27me3 during activation of human na{\"\i}ve and memory CD4 T cells. Our results show that these changes occur relatively early (1 day) after activation of both na{\"\i}ve and memory cells, and that H3K27 demethylation is the predominant change at this time point, reinforcing high expression of target genes. Additionally, we also examined bivalent gene promoters (i.e. those containing both H3K4me3 and H3K27me3) and show that this state is dynamic during activation with different outcomes comparing na{\"\i}ve and memory subsets, despite strong overlap between mapped functional pathways. Additionally, inhibition of the H3K27 demethylase, JMJD3, in na{\"\i}ve CD4 demonstrates how the critical JAK/STAT pathways are regulated during activation by H3K27 demethylation. Our results demonstrate that H3K27me3 is a dynamic and important epigenetic modification during CD4 T cell activation and differentiation, and that JMJD3-driven H3K27 demethylation is integral to CD4 T cell function.},
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Author = {LaMere, Sarah and {\textbf{Ryan C. Thompson}} and Meng, Xiangzhi and Komori, H. Kiyomi and Mark, A. and Salomon, Daniel R.},
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Date-Added = {2016-10-25 21:40:16 +0000},
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- Date-Modified = {2016-10-25 22:04:38 +0000},
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- Journal = {Proceedings of the National Academy of Sciences (in review)},
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+ Date-Modified = {2017-03-31 21:12:35 +0000},
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+ Journal = {Journal of Immunology (in review)},
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Title = {{{H3K27} methylation dynamics during {CD4} {T} cell activation: regulation of {JAK}/{STAT} and {IL12RB2} expression by {JMJD3}}},
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Year = {2017}}
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