GnRH binds to its receptor, the GnRH receptor, on gonadotrophic cells of the anterior pituitary. Activating this G protein-coupled receptor triggers a cascade of events that stimulates the synthesis and launch of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH, in flip, www.valley.md bind to their cognate receptors on the Leydig cells and Sertoli cells of the testis, respectively. LH stimulates testosterone manufacturing and, at the aspect of FSH, regulates spermatogenesis. Testosterone, and its estrogenic metabolite estradiol, exert adverse suggestions on the hypothalamus and pituitary to suppress their own synthesis (173, 174). Estradiol in particular is very potent at suppressing gonadotropin secretion as, on a molar foundation, it is estimated to be 200-fold stronger than testosterone in doing so (175). We think about Dianabol the better steroid for building pure mass