In line with Rica Lewis in an solicitor article in Livestrong she explains that yo-yo dieting causes a decrease within the body's immune system.

For instance, methods about placing obstacles between ourselves and unhealthy meals make the most of most people's tendencies toward laziness.

The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and that are structurally not associated to SET-area proteins 4 - 6 Recent work means that SET-area-containing proteins methylate a number of proteins along with histones (see later)