The enzymes concerned in lysine methylation had been first found to target histone and thus had been initially named histone methyltransferases and histone demethylases, following the naming model for histone acetyltransferase and histone deacetylase.

We recognized histone H3 lysine 27 acetylation (H3K27Ac) as a modification upregulated in CRC, which had not been shown beforehand.

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